Metabolic Stability Testing

Drugs are eliminated by biotransformation in the liver through phase I and II reactions and/or excretion in urine and bile. Metabolic stability affects both the oral bioavailability and the plasma half life of a compound and thus its efficacy. Therefore, the knowledge of metabolic stability is essential in drug discovery and development. CANTEST offers metabolic stability evaluation in various test systems. Typically, compounds are incubated in test systems and aliquots of samples are taken at pre-determined times. The loss of a parent compound is determined by LC-MS/MS.