Oral Bioavailability

Effective delivery of drugs to the biological site of action (e.g. intravenous or oral bioavailability) is influenced by the solubility of the drug. Aqueous solubility is a key predictor of oral bioavailability and toxicity of drug candidates. Oral drugs must be absorbed through the gastrointestinal tract and remain in solution to reach the intended therapeutic target. CANTEST determines aqueous solubility of organic compounds at pH values from 0 to 14 in different buffer systems.