Gas Chromatography Mass Spectrometry

GC-MS is commonly used to identify and quantify volatile compounds. Non-volatile analytes may also be determined following derivatization. Components in the sample are vaporized in a stream of helium carrier gas and run through a column. Molecules are then ionized and separated according to their mass to charge ratio.

GC-MS combines the selectivity of gas chromatography with the sensitivity of mass spectrometry for detection. Where sensitivity is not a priority, conventional flame ionization detection (FID) may be employed.

These techniques are particularly suitable for characterization, identification and quantitation of volatile and semi-volatile organic compounds with relatively low molecular weights (<400 Daltons). GC-MS can also be used to characterize unknown components in a sample by comparing retention times with the comprehensive NIST database library.

Specific applications include the following:

• Fatty Acid Analysis
• Phthalates
• % Purity Checks