Inductively Coupled Plasma Mass Spectrometry

The ICPMS is commonly used to measure trace elements in a variety of sample types. When it is coupled to either gas or liquid chromatography, more specific information such as valency, molecular state and protein binding properties can be obtained.

Chromatography coupled ICPMS is also used to detect metal-ligand complexes, which is useful when the ligand has no chromophore or is not amenable to detection by other techniques. Specific applications include the following:

• Proposition 65 Pb Testing of OTC personal care products and medications
• Residual Catalyst Determination
• Extended list of 67 elements (Full-scan)
• Heavy Metals analysis
• Metals Speciation
• Bioanalysis of Metallo-Drugs in support of Pharmacokinetic and other studies

Enhanced ICP-MS

Enhanced ICPMS involves the use of alternative sample introduction systems, such as a desolvation apparatus, plasma conditions, such as cold plasma, or analyzer modifications, such as collision/ reaction cells to enhance sensitivity or remove matrix interferences thereby lowering detection limits.